Direct Blue Dyes is an organic compound that is one of many azo dyes. This salt is used as a substantive dye for textiles with high contents of cellulose, i.e. cotton. It is prepared by the azo coupling of the amino naphthalene and diazotized derivative of o-dianisidine. Direct Blue Dyes are widely used to help identify sentinel lymph nodes in oncological surgery. The rate of severe allergic reactions to blue dyes remains a controversial topic, with the true incidence and influencing factors uncertain.
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